�Together with colleagues from the Department of Dermatology and Allergy and the Center for Allergy and Environment (ZAUM) of the Technische Universitat Munchen, scientists at the Helmholtz Zentrum Munchen let pinpointed a major cistron for supersensitive diseases. The gene was localized victimisation cutting edge technologies for examining the whole human genome at the Helmholtz Zentrum Munchen.
Schematic representation of the heights affinity receptor for IgE. Variants inside the gene encoding the alpha chain are associated with increased levels of IgE antibodies
The newly discovered FCER1A gene encodes the alpha chain of highschool affinity IgE receptor, which plays a major character in controlling allergic responses. The team of scientists led by Dr. Stephan Weidinger from the Technische Universit�t M�nchen and Dr. Thomas Illig from the Helmholtz Zentrum M�nchen institute that sure variations of the FCER1A gene decisively influence the production of immunoglobulin E (IgE) antibodies. IgE antibodies are a particular type of antibody that is normally used to protect against parasites. In Western lifestyle countries with less contact, yet, elevated IgE levels ar associated with allergic disorders.
In genetically susceptible individuals the immune system becomes slanted and produces IgE antibodies against harmless agents such as pollen, dust mites or animal hair. These IgE antibodies then work in conjunction with sure cells to get rid of the allergens, a process that gives rise to the symptoms of allergy such as allergic rhinitis (hay fever), atopic dermatitis or asthma.
"Most people with allergies are atopic - meaning they possess a genetic tendency to develop allergies. To find the hereditary factors we examined the genomes of more than 10,000 adults and children from the whole of Germany" explained Stephan Weidinger.
Most of the persons examined for the study come from the population studies of the KORA (co-operative wellness research in the Augsburg region) inquiry platform, which is light-emitting diode by Prof. Dr. H.-Erich Wichmann, the Director of the Institute of Epidemiology at the Helmholtz Zentrum M�nchen. The allergological examinations were carried by the Department for Dermatology and Allergy of the Technische Universit�t M�nchen headed by Prof. Dr. Dr. Johannes Ring.
Although in its former stages, the new noesis on the regulation of IgE production does have the potentiality to template the ontogenesis of fresh drugs.
Publication:
Weidinger S, Gieger C, Rodriguez E, Baurecht H, Mempel M, et al. (2008) Genome-Wide Scan on Total Serum IgE Levels Identifies FCER1A as Novel Susceptibility Locus. PLoS Genet 4(8): e1000166. interior Department: 10.1371/journal.pgen.1000166
http://www.plosgenetics.org/doi/pgen.1000166
Source: Heinz Joerg Haury
Helmholtz Zentrum M�nchen - German Research Center for Environmental Health
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Friday 29 August 2008
Saturday 9 August 2008
Panta Rhei
Artist: Panta Rhei
Genre(s):
Ambient
New Age
Other
Discography:
Epilogus
Year: 1997
Tracks: 17
Rainbow dancers
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Tracks: 12
Radujnaia Tancovshica
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Panta Rhei
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